| Comments |
Restriction digests of the clone give the following sizes (kb): EcoRI--23.1, 13.1, 8.4, 5.3, 2.4, 1.24; BglI--23.1, 9.9, 5.1, 5.0, 2.2, 2.1, 1.8, 1.39, 0.71; BamHI--19.1, 13.7, 7.9, 6.0, 4.1, 2.6, 1.6, 1.11; PstI--14.4, 9.8, 5.6, 4.1, 3.3, 3.1, 2.8 (doublet), 2.1, 1.83, 1.35, 1.25, 1.16; HindIII--27.9, 6.0, 3.7, 1.67, 1.33, 0.94, 0.93. The HindIII and MspI polymorphisms have a combined PIC value of 0.62 and a combined heterozygosity of 64%. Enzyme(s) not detecting polymorphism: BglII, EcoRI, HincII, BamHI, PstI, RsaI, TaqI (panel of 5 individuals). |
| References |
Schumm JW, et al. Identification of more than 500 RFLPs by screening random genomic clones. Am. J. Hum. Genet. 42: 143-159, 1988. PubMed: 2892396
Donis-Keller H, et al. A genetic linkage map of the huma genome. Cell 51: 319-337, 1987. PubMed: 3664638
Keith TP, et al. Genetic linkage map of 43 DNA markers on human chromosome 16. Proc. Natl. Acad. Sci. USA 87: 5754-5758, 1990. PubMed: 2377614
Jacobsen SJ, et al. A clinically homogeneous group of families with facioscapulohumeral (Landouzy-Dejerine) muscular dystrophy: linkage analysis of six autosomes. Am. J. Hum. Genet. 47: 376-388, 1990. PubMed: 1975474
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